Sodium borohydride → 9-Hydroxymethyl-9,10-dihydro-9,10-methanoanthracene

HRID 27958노트

반응식

HRID 27958 반응식
[CH:1]([C:3]12[CH2:17][CH:10]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=31)[C:9]1[C:4]2=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:2].[BH4-].[Na+]>CO.O>[OH:2][CH2:1][C:3]12[CH2:17][CH:10]([C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=31)[C:11]1[C:16]2=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 124041419,10-Dihydro-9,10-methanoanthracene-9-carboxaldehyde

생성물 1

HCID 130690829-Hydroxymethyl-9,10-dihydro-9,10-methanoanthracene

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 9-formyl-9,10-dihydro-9,10-methanoanthracene (200 mg) and sodium borohydride (60 mg) in methanol (5 ml) was stirred at room temperature for 30 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness to give 9-hydroxymethyl-9,10-dihydro-9,10-methanoanthracene. M.P. 165°-166° C.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-d3dee8af744947a4a49fd88610cdbe85
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04224344

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