HCID 22624891, 화합물 → 2-(Pyridin-3-yloxy)ethan-1-ol

HRID 279630

반응식

HRID 279630 반응식
O1CCCCC1[O:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1>C(O)(=O)C.C1COCC1.O>[OH:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1

참가 물질

5

반응물 1

HCID 22624891HCID 22624891, 화합물

생성물 1

HCID 219089972-(Pyridin-3-yloxy)ethan-1-ol수율 86%

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-(2-(tetrahydropyran-2-yloxy)ethoxy)pyridine (1.54 g, 7 mmol) in acetic acid (8 ml), THF (4 ml) and water (2 ml) was heated at 50° C. for 4 hours. The volatiles were removed by evaporation and the residue azeotroped with toluene to give 3-(2-hydroxyethoxy)pyridine (820 mg, 86%) as an off-white solid.

후처리

  1. customThe volatiles were removed by evaporation
  2. customthe residue azeotroped with toluene

출처 및 근거

ORD 기록
ord-27d37db75bc147aaac8aa4d41bb8802f
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362336B1

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