1H-Imidazole-4,5-dicarboxylic acid, 4,5-dimethyl ester → 1H-Imidazole-4,5-dimethanol

HRID 279846

반응식

HRID 279846 반응식
[NH:1]1[C:5]([C:6](OC)=[O:7])=[C:4]([C:10](OC)=[O:11])[N:3]=[CH:2]1>O1CCCC1>[OH:7][CH2:6][C:5]1[N:1]=[CH:2][NH:3][C:4]=1[CH2:10][OH:11]

참가 물질

3

반응물 1

HCID 768101H-Imidazole-4,5-dicarboxylic acid, 4,5-dimethyl ester

생성물 1

HCID 5736291H-Imidazole-4,5-dimethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Reflux dimethyl 4,5 imidazole dicarboxylate (1.8 g) in THF (tetrahydrofuran) with 2.5 equivalents of LAH lithium aluminum hydride). Neutralize with NH4Cl solution and filter. Concentrate the filtrate under vacumm and extract the product with ethanol. Remove the solvent, filtrate through alumina using a THF solvent to give the title compound.

후처리

  1. filtrationNeutralize with NH4Cl solution and filter
  2. concentrationConcentrate the filtrate under vacumm
  3. extractionextract the product with ethanol
  4. customRemove the solvent, filtrate through alumina using a THF solvent

출처 및 근거

ORD 기록
ord-12483586f11b49f08bb683b241c74f50
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04587241

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