Water → (8aR-trans)-octahydro-1-propyl-6(2H)-quinolinone

HRID 279958

반응식

HRID 279958 반응식
O.CC1(C)CO[C:6]2([CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]2)OC1.[CH2:16]([NH2:19])[CH2:17][CH3:18].O.[C:21]1(C)[CH:26]=CC(S(O)(=O)=O)=C[CH:22]=1>C1(C)C=CC=CC=1>[CH2:16]([N:19]1[C@H:6]2[C@@H:9]([CH2:10][C:11](=[O:14])[CH2:12][CH2:13]2)[CH2:26][CH2:21][CH2:22]1)[CH2:17][CH3:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 7852PropylamineHCID 521998p-Toluenesulfonic acid monohydrateHCID 5879683,3-Dimethyl-1,5-dioxaspiro(5.5)undecan-9-one

생성물 1

HCID 13457872(8aR-trans)-octahydro-1-propyl-6(2H)-quinolinone

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A 250 ml single neck round bottom flask fitted with a water separator containing 20 g of 3A sieves (Linde) was charged with 100 ml of toluene, 10.25 g (0.052 mol) of 3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-one (Aldrich Chemical Company), 17.97 g (3.04 mmol) of n-propylamine (Baker) and 18 mg (0.09 mmol) of p-toluenesulfonic acid monohydrate (Aldrich). The reaction mixture was refluxed for 24 hours and cooled, and the toluene was evaporated under reduced pressure to produce the title compound.

후처리

  1. temperatureThe reaction mixture was refluxed for 24 hours
  2. temperaturecooled
  3. customthe toluene was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-5a4c264c5471459b8d3a8fecca54cb00
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04587351

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