Hydrochloric Acid → 3-Trifluoroacetylfuran
반응식
Br[C:2]1[CH:6]=[CH:5][O:4][CH:3]=1.C([Li])CCC.[F:12][C:13]([F:20])([F:19])[C:14](OCC)=[O:15].Cl>C(OCC)C>[F:12][C:13]([F:20])([F:19])[C:14]([C:2]1[CH:6]=[CH:5][O:4][CH:3]=1)=[O:15]참가 물질
6
실험 절차
3-Bromofuran (20 g) was added to a solution of n-butyllithium (2.5M in hexanes, 60 ml) in diethyl ether (200 ml) at -70° C. After 30 minutes, ethyl trifluoroacetate (28.6 g) was added slowly. After a further 1 hour the mixture was allowed to warm to room temperature and was then left to stir overnight. 1M Hydrochloric acid (100 ml) was added and the mixture stirred for 5 minutes. The organic layer was separated, washed, dried and evaporated. The residue was distilled to give the title compound. B.p. 118° C.
후처리
- waitAfter a further 1 hour the mixture was allowed
- waitwas then left
- stirringthe mixture stirred for 5 minutes
- customThe organic layer was separated
- washwashed
- customdried
- customevaporated
- distillationThe residue was distilled
출처 및 근거
- ORD 기록
- ord-ca2c656728094237986dc15e1b9e16c6
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05731335
반응 노트
불러오는 중…