6-Oxoheptanoic acid → Nalpha-Acetyl-p-(6-Oxo-n-Heptanoylamino)-L-Phenylalanyl-Glycine Benzyl Ester

HRID 280045

반응식

HRID 280045 반응식
C(OC(=O)CNC(=O)[C@H](CC1C=CC([N+]([O-])=O)=CC=1)NC(OC(C)(C)C)=O)C1C=CC=CC=1.[O:34]=[C:35]([CH3:43])[CH2:36][CH2:37][CH2:38][CH2:39][C:40]([OH:42])=O.[CH2:44]([O:51][C:52](=[O:70])[CH2:53][NH:54][C:55](=[O:69])[C@H:56]([CH2:61][C:62]1[CH:67]=[CH:66][C:65]([NH2:68])=[CH:64][CH:63]=1)[NH:57][C:58](=[O:60])[CH3:59])[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1>CO>[CH2:44]([O:51][C:52](=[O:70])[CH2:53][NH:54][C:55](=[O:69])[C@H:56]([CH2:61][C:62]1[CH:67]=[CH:66][C:65]([NH:68][C:40](=[O:42])[CH2:39][CH2:38][CH2:37][CH2:36][C:35](=[O:34])[CH3:43])=[CH:64][CH:63]=1)[NH:57][C:58](=[O:60])[CH3:59])[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1

참가 물질

5

반응물 3

HCID 988106-Oxoheptanoic acidHCID 13934182Nalpha-t-Butyloxycarbonyl-p-Nitro-L-Phenylalanyl-Glycine Benzyl EsterHCID 54160731Nalpha-Acetyl-p-Amino-L-Phenylalanyl-Glycine Benzyl Ester

생성물 1

HCID 53767188Nalpha-Acetyl-p-(6-Oxo-n-Heptanoylamino)-L-Phenylalanyl-Glycine Benzyl Ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The mixed anhydride coupling was performed as described for the synthesis of compound 13 with 6-oxo-n-heptanoic acid (97 mg, 0.67 mmol) and the product from above, compound 15 (238 mg, 0.67 mmol). Each component was dissolved in 10 ml of dry tetrahydrofaran. Yield 111 mg (34%), mp 177.5°-180.5° C., [α]D25 =+19.5 (c.=1.4, methanol). Anal. calc. for C27H33N3O6 (493.58): C, 65.44; H, 6.71; N, 8.48. Found: C, 65.46; H, 6.74; N, 8.61.

후처리

  1. dissolutionEach component was dissolved in 10 ml of dry tetrahydrofaran

출처 및 근거

ORD 기록
ord-27bd1b361a22467289ac874c4e5e9004
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04587046

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