Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Oxoheptanoic acid → Nalpha-Acetyl-p-(6-Oxo-n-Heptanoylamino)-L-Phenylalanyl-Glycine Benzyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Oxoheptanoic acid | HCID 98810 | — |
| 반응물 | Nalpha-t-Butyloxycarbonyl-p-Nitro-L-Phenylalanyl-Glycine Benzyl Ester | HCID 13934182 | — |
| 반응물 | Nalpha-Acetyl-p-Amino-L-Phenylalanyl-Glycine Benzyl Ester | HCID 54160731 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Nalpha-Acetyl-p-(6-Oxo-n-Heptanoylamino)-L-Phenylalanyl-Glycine Benzyl Ester | HCID 53767188 | — |
반응 단계
The mixed anhydride coupling was performed as described for the synthesis of compound 13 with 6-oxo-n-heptanoic acid (97 mg, 0.67 mmol) and the product from above, compound 15 (238 mg, 0.67 mmol). Each component was dissolved in 10 ml of dry tetrahydrofaran. Yield 111 mg (34%), mp 177.5°-180.5° C., [α]D25 =+19.5 (c.=1.4, methanol). Anal. calc. for C27H33N3O6 (493.58): C, 65.44; H, 6.71; N, 8.48. Found: C, 65.46; H, 6.74; N, 8.61.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04587046 |
| 출처 데이터셋 | uspto-grants-1986_05 |
| ORD ID | ord-27bd1b361a22467289ac874c4e5e9004 |
| 출처 메모 | uspto-grants-1986_05 |