Diethyl Ether → N-(3-hydroxypropyl)-2,3,4-trimethoxy-benzenesulfonamide

HRID 280053

반응식

HRID 280053 반응식
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[S:13](Cl)(=[O:15])=[O:14].[NH2:17][CH2:18][CH2:19][CH2:20][OH:21].C(OCC)C>C(Cl)Cl>[OH:21][CH2:20][CH2:19][CH2:18][NH:17][S:13]([C:4]1[CH:5]=[CH:6][C:7]([O:11][CH3:12])=[C:8]([O:9][CH3:10])[C:3]=1[O:2][CH3:1])(=[O:15])=[O:14]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 90863-Amino-1-propanolHCID 47127422,3,4-trimethoxybenzenesulfonyl Chloride

생성물 1

HCID 13645632N-(3-hydroxypropyl)-2,3,4-trimethoxy-benzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2,3,4-Trimethoxybenzene sulfonyl chloride (20.4 g, 0.765 m) in methylene chloride (100 ml) was added dropwise to 3-aminopropanol (17.2 g) in methylene chloride (300 ml). After stirring overnight the reaction was washed with dilute aqueous HCl, dried and stripped to provide a solid. Trituration with diethyl ether provided the product N-(3-hydroxypropyl)-2,3,4-trimethoxy-benzenesulfonamide, m.p. 95°-97° C.

후처리

  1. washwas washed with dilute aqueous HCl
  2. customdried
  3. customto provide a solid

출처 및 근거

ORD 기록
ord-2a8de3b233524fb4987aa632861c0049
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04587360

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