Triethylamine → HCID 13478097, 화합물

HRID 280096

반응식

HRID 280096 반응식
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:12][C:13]1[CH:28]=[CH:27][C:16]([O:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:15][CH:14]=1.C(N(CC)CC)C>C(O)(C)C>[F:12][C:13]1[CH:14]=[CH:15][C:16]([O:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][N:24]([C:2]3[N:11]=[CH:10][C:9]4[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=4)[N:3]=3)[CH2:25][CH2:26]2)=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 740542-ChloroquinazolineHCID 18733961-[3-(4-Fluorophenoxy)propyl]piperazine

생성물 1

HCID 13478097HCID 13478097, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

2.5 g 2-Chloro-quinazoline, 3.8 g 1-[3-(4-fluorophenoxy)propyl]piperazine and 2.5 ml triethylamine in 15 ml isopropanol are stirred under reflux for 5 hours. The solvent is then evaporated in vacuo and the residue partitioned between water and methylene chloride. The organic phase is dried and evaporated. The residue is recrystallized from ethanol to yield the title compound, m.p. 126°-128° C.

후처리

  1. temperatureunder reflux for 5 hours
  2. customThe solvent is then evaporated in vacuo
  3. customthe residue partitioned between water and methylene chloride
  4. customThe organic phase is dried
  5. customevaporated
  6. customThe residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-87f2de8023f14f53ac1b7ff2295fa747
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588725

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