Sodium Hydroxide → 5-(4-Carboxybuta-1,3-dienyl)-imidazo[1,5-a]pyridine
반응식
C([O:3][C:4]([CH:6]=[CH:7][CH:8]=[CH:9][C:10]1[N:15]2[CH:16]=[N:17][CH:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)=[O:5])C.[OH-].[Na+]>CO>[C:4]([CH:6]=[CH:7][CH:8]=[CH:9][C:10]1[N:15]2[CH:16]=[N:17][CH:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)([OH:5])=[O:3]참가 물질
4
실험 절차
To a solution of 200 mg of 5-(4-ethoxycarbonylbuta-1,3-dienyl)imidazo[1,5-a]pyridine in 20 ml of methanol is added 4 ml of 1N sodium hydroxide. The reaction mixture is stirred at room temperature for 18 hours. The methanol is evaporated under reduced pressure and the residue diluted with 20 ml of water and the solution is adjusted to pH 5 with hydrochloric acid. The precipitate is collected to give 5-(4-carboxybuta-1,3-dienyl)-imidazo[1,5-a]pyridine, melting at 243°-245°.
후처리
- customThe methanol is evaporated under reduced pressure
- additionthe residue diluted with 20 ml of water
- customThe precipitate is collected
출처 및 근거
- ORD 기록
- ord-7e00622a39854c5db365d0fb36351fff
- 출처 데이터셋
- uspto-grants-1986_05
- 특허 번호
- US04588732
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