Thionyl Chloride → 5-(Chloromethyl)imidazo[1,5-a]pyridine

HRID 280230노트

반응식

HRID 280230 반응식
[CH:1]([C:3]1[N:8]2[CH:9]=[N:10][CH:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1)=O.[BH4-].[Na+].OCC1N2C=NC=C2C=CC=1.S(Cl)([Cl:27])=O>>[Cl:27][CH2:1][C:3]1[N:8]2[CH:9]=[N:10][CH:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1

참가 물질

5

반응물 4

HCID 24386Thionyl ChlorideHCID 4311764Sodium borohydrideHCID 13206163Imidazo(1,5-a)pyridine-5-carbaldehydeHCID 23321868Imidazo[1,5-a]pyridin-5-ylmethanol

생성물 1

HCID 233218555-(Chloromethyl)imidazo[1,5-a]pyridine

실험 절차

5-Chloromethylimidazo[1,5-a]pyridine is prepared from 5-formylimidazo-[1,5-a]pyridine by reduction with sodium borohydride to 5-hydroxymethylimidazo[1,5-a]pyridine and subsequent treatment with thionyl chloride.

출처 및 근거

ORD 기록
ord-b350f305caaf474c99183e1491f8b558
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588732

반응 노트

불러오는 중…