4-Nitrophenol → Diethyl[2-(4-nitrophenoxy)ethyl]amine

HRID 280256

반응식

HRID 280256 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[H-].[Na+].[CH2:13]([N:15]([CH2:19][CH3:20])[CH2:16][CH2:17]Cl)[CH3:14]>CN(C=O)C>[CH2:13]([N:15]([CH2:19][CH3:20])[CH2:16][CH2:17][O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)[CH3:14]

참가 물질

5

반응물 3

HCID 9804-NitrophenolHCID 13364Diethylaminoethyl chlorideHCID 24758Sodium hydride

생성물 1

HCID 88294Diethyl[2-(4-nitrophenoxy)ethyl]amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a cold solution of 41.8 g of 4-nitrophenol in 250 ml of DMF was added 16.0 g of a 57% dispersion of sodium hydride in mineral oil, followed by 46.0 g of 2-diethylaminoethyl chloride. After 20 hours, the mixture was filtered, freed of solvent by evaporation under reduced pressure, the residue dissolved in ether and washed with water. Extraction with 2N hydrochloric acid and basification of the extract gave N,N-diethyl-2-(4-nitrophenoxy)ethanamine.

후처리

  1. filtrationthe mixture was filtered
  2. customfreed of solvent by evaporation under reduced pressure
  3. dissolutionthe residue dissolved in ether
  4. washwashed with water
  5. extractionExtraction with 2N hydrochloric acid and basification of the extract

출처 및 근거

ORD 기록
ord-8642a758cc744568a9c3812c649ac4ca
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588730

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