2-(3-Chlorophenyl)-2-oxoacetaldehyde → N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine

HRID 280316

반응식

HRID 280316 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([CH:10]=O)=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([CH3:24])([CH3:23])[NH2:22])=[CH:15][CH:14]=1>>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([NH:22][CH2:10][CH:8]([OH:9])[C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)([CH3:23])[CH3:24])=[CH:15][CH:14]=1

참가 물질

3

반응물 2

HCID 124638932-(3-Chlorophenyl)-2-oxoacetaldehydeHCID 233221672-Methyl-4-(4-methylphenyl)butan-2-amine

생성물 1

HCID 23322177N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine

실험 절차

The title compound was prepared in the manner described in Example 9 using 3-chlorophenylglyoxal and 3-(4-methylphenyl)-1,1-dimethylpropanamine. The chromatographed material was recrystallized from cyclohexane to give the title compound m.p. 136. τ(CDCL3 +d6DMSO) 8.9 (6H, s), 8.2-8.4 (2H, m), 7.7 (3H, s), 7.0-7.6 (4H, m), 5.35 (1H, dd), 2.9 (4H, s), 2.5-2.7 (5H, m).

후처리

  1. customThe title compound was prepared in the manner
  2. customThe chromatographed material was recrystallized from cyclohexane

출처 및 근거

ORD 기록
ord-2d8e56e2bf444a0ab85fdddb57b92ca8
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588749

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