Thionyl Chloride → HCID 23321750, 화합물

HRID 280337노트

반응식

HRID 280337 반응식
O[CH2:2][CH2:3][N:4]1[C:9](=[O:10])[CH:8]=[CH:7][NH:6][C:5]1=[O:11].S(Cl)([Cl:14])=O>ClC(Cl)Cl>[Cl:14][CH2:2][CH2:3][N:4]1[C:9](=[O:10])[CH:8]=[CH:7][NH:6][C:5]1=[O:11]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 152168273-(2-Hydroxyethyl)pyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 23321750HCID 23321750, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a stirred solution of 3 parts of 3-(2-hydroxyethyl)-2,4(1H,3H)-pyrimidinedione and 45 parts of trichloromethane were added dropwise 8 parts of thionyl chloride. Upon completion, stirring was continued for 1 hour at reflux temperature. The reaction mixture was cooled. The precipitated product was filtered off and crystallized from 2-propanol, yielding 3.1 parts of 3-(2-chloroethyl)-2,4(1H,3H)-pyrimidinedione; mp. 170° C. (60).

후처리

  1. temperatureat reflux temperature
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe precipitated product was filtered off
  4. customcrystallized from 2-propanol

출처 및 근거

ORD 기록
ord-ed9b37555b154b1cb10928446638c003
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588722

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