Ethylene Oxide → 3-Phenoxy-1,2-propanediol

HRID 280359

반응식

HRID 280359 반응식
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.C1C2NC3C(=CC=CC=3)SC=2C=CC=1.[O:26]1CC1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>[Br-].C([N+](CCC)(CCC)CCC)CC.C1(C)C=CC=CC=1>[O:5]([CH2:1][CH:2]([OH:4])[CH2:3][OH:26])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

7

반응물 4

HCID 6354Ethylene OxideHCID 7108PhenothiazineHCID 31217Phenyl glycidyl etherHCID 521998p-Toluenesulfonic acid monohydrate

생성물 1

HCID 108573-Phenoxy-1,2-propanediol

시약·촉매·용매 2

HCID 74745Tetrapropylammonium bromide촉매HCID 1140Toluene용매2회

실험 절차

A solution of 150.2 g. phenyl glycidyl ether (1.0 eq.), 200.0 g. AOnPA (1.15 eq., of Example 1), 200.0 g. toluene, 4.0 g. tetrapropylammonium bromide (0.015 eq.), and 1.0 g. phenothiazine was heated at reflux for 6.0 hours. Conversion, measured by residual oxirane titer, was ca. 93%. Upon cooling, the reactor was charged with 186.0 g. of AOnPA (1.07 eq.), 150.0 g. toluene, and 10.0 g. p-toluenesulfonic acid monohydrate (0.05 eq.). The mixture was again heated at reflux. After 6.0 hrs., conversion was 90%. The product was extracted with ether and purified by washing. It had an acrylate titer of 3.8 meq./g. (theory: 4.17 meq./g.) and Brookfield viscosity of 230 centipoise at 25° C.

후처리

  1. temperatureat reflux for 6.0 hours
  2. temperatureUpon cooling
  3. additionthe reactor was charged with 186.0 g
  4. temperatureThe mixture was again heated
  5. temperatureat reflux
  6. extractionThe product was extracted with ether
  7. custompurified
  8. washby washing
  9. customat 25° C.

출처 및 근거

ORD 기록
ord-a1c7bf51043e43aab9ac5c08ae5136df
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588788

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