Pyrazine → 1-(2-Pyrazinyl)-2,2-dimethylpropanone

HRID 280363

반응식

HRID 280363 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][CH:2]=1.[CH3:7][C:8]([CH3:12])([CH3:11])[CH:9]=[O:10]>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:9](=[O:10])[C:8]([CH3:12])([CH3:11])[CH3:7]

참가 물질

4

반응물 2

HCID 9261PyrazineHCID 12417Pivalaldehyde

생성물 1

HCID 5460311-(2-Pyrazinyl)-2,2-dimethylpropanone수율 11%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The reaction of pyrazine and trimethylacetaldehyde is conducted in the manner described in Example I on the same molar scale. Preparative thick layer chromatography (2000μ silica gel GF, developed with methylene chloride) of the crude reaction product provides an 11% yield of 1-pyrazinyl-2,2-dimethyl-1-propanone.

출처 및 근거

ORD 기록
ord-78d20b627add4015a20ffd02abad92f2
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588813

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