Hydrochloric Acid → HCID 178478599, 화합물

HRID 280410노트

반응식

HRID 280410 반응식
[NH2:1][C:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:13]=2)=[N:5]S(=O)[N:3]=1.[ClH:25]>CO>[ClH:25].[ClH:25].[ClH:25].[N:19]1([CH2:18][C:14]2[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=2)[O:11][CH2:10][CH2:9][CH2:8][NH:7][C:6](=[NH:5])[C:2](=[NH:1])[NH2:3])[CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 159612053-Amino-4-[3-(3-pyrrolidinomethylphenoxy)propylamino]-1,2,5-thiadiazole 1-oxide

생성물 1

HCID 178478599HCID 178478599, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of 3-amino-4-[3-(3-pyrrolidinomethylphenoxy)propylamino]-1,2,5-thiadiazole 1-oxide (13.4 g; 38.3 mmoles) [prepared according to published United Kingdom Patent Application No. 2,067,987] in 350 mL of methanol was treated with 25.5 mL of concentrated HCl. The resultant solution was stirred for 3 hours at ambient temperature. Concentration of the solution followed by azeotropic removal of water with absolute ethanol gave the product. The crystalline residue was triturated with 150 mL of absolute ethanol, filtered and dried to give 10.8 g of the title compound, m.p. 195°-203° C. (dec.).

후처리

  1. customConcentration of the solution followed by azeotropic removal of water with absolute ethanol
  2. customgave the product
  3. customThe crystalline residue was triturated with 150 mL of absolute ethanol
  4. filtrationfiltered
  5. customdried

출처 및 근거

ORD 기록
ord-67600ac76f594e069032c0ec7610aa71
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04588826

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