Hydrochloric Acid → 2-Methylbenzo[b]thiophene-5-carboxylic acid methyl ester

HRID 280593노트

반응식

HRID 280593 반응식
[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:4]=2[CH:3]=1.Cl.[CH3:15]O>>[CH3:15][O:12][C:11]([C:9]1[CH:8]=[CH:7][C:5]2[S:6][C:2]([CH3:1])=[CH:3][C:4]=2[CH:10]=1)=[O:13]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1366303686792-71-4

생성물 1

HCID 136630372-Methylbenzo[b]thiophene-5-carboxylic acid methyl ester

실험 절차

A solution of 2-methylbenzo[b]thiophene-5-carboxylic acid (17.4 g) in methanol (250 ml) was saturated with hydrogen chloride and then heated under reflux for 30 minutes. The solid which crystallised out on cooling was filtered off and dried to give 2-methylbenzo[b]thiophene-5-carboxylic acid methyl ester (16.7 g), m.p. 97°-98°.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 30 minutes
  3. customThe solid which crystallised out
  4. temperatureon cooling
  5. filtrationwas filtered off
  6. customdried

출처 및 근거

ORD 기록
ord-60f6a7c3f90f486e81a98c3f04d62b26
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04590200

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