Ethyl vinyl ether → 2,5-dimethyl-4-[(1'-ethoxy)ethoxy]-3(2H)-furanone

HRID 280711

반응식

HRID 280711 반응식
[CH3:1][CH:2]1[C:6](=[O:7])[C:5]([OH:8])=[C:4]([CH3:9])[O:3]1.[CH:10]([O:12][CH2:13][CH3:14])=[CH2:11].C(=O)(O)[O-].[Na+]>Cl>[CH3:9][CH:4]1[C:5](=[O:8])[C:6]([O:7][CH:10]([O:12][CH2:13][CH3:14])[CH3:11])=[C:2]([CH3:1])[O:3]1

참가 물질

5

반응물 3

HCID 8023Ethyl vinyl etherHCID 19309FuraneolHCID 516892Sodium Bicarbonate

생성물 1

HCID 233212762,5-dimethyl-4-[(1'-ethoxy)ethoxy]-3(2H)-furanone수율 80.8%

시약·촉매·용매 1

HCID 313Hydrochloric Acid촉매

실험 절차

To a heterogenous solution of 2,5-dimethyl-4-hydroxy-3-(2H)-furanone (133.0 g, 1.0 mole) and ethyl vinyl ether (144.0 g, 2.0 moles) at 10° C., under N2, is added dropwise, concentrated hydrochloric acid (1.0 g). The temperature rises to 11° C. and the solution becomes homogeneous. It is stirred for 1.5 hours, and then the coolant is removed. Stirring is continued at room temperature for an additional six hours, after which the reaction is quenched by the addition of solid sodium bicarbonate (10 g, 0.12 mole). The reaction mixture is washed with 100 ml water and a second time with 100 ml of 5% NaHCO3. The product is dried over Na2SO4 and distilled to give a 78.9% yield (161.8 g) of 2,5-dimethyl-4-[(1'-ethoxy)ethoxy]-3(2H)-furanone, b.p. 91° C. (0.05 torr), IR (neat, film) 1200, 1625, 1700, 2030, 2978 cm-1 ; 1H NMR (CDCl3) δ1.20 (t, J=8 Hz, 3), 1.32 (d, J=5 Hz, 3), 1.42 (d, J=7 Hz, 3), 2.2 (S, 3), 3.72 (m, 2), 4.48 (q, J=7 Hz, 1), 5.32 (q, J=5 Hz, 1).

후처리

  1. customrises to 11° C.
  2. customthe coolant is removed
  3. stirringStirring
  4. waitis continued at room temperature for an additional six hours
  5. washThe reaction mixture is washed with 100 ml water
  6. dry with materialThe product is dried over Na2SO4
  7. distillationdistilled

출처 및 근거

ORD 기록
ord-4dcb7ad850974758914ce18c7de99969
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04590284

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