Diphenyl Ether → Methyl-5-(2-chloro-4-cyano-6-fluoro-phenoxy)-2-nitro-benzoate

HRID 280728

반응식

HRID 280728 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:11])[C:9]=1F)[C:5]#[N:6].C1(OC2C=CC=CC=2)C=CC=CC=1.[K].[CH3:26][O:27][C:28](=[O:39])[C:29]1[CH:34]=[C:33]([OH:35])[CH:32]=[CH:31][C:30]=1[N+:36]([O-:38])=[O:37]>CN1CCCC1=O>[CH3:26][O:27][C:28](=[O:39])[C:29]1[CH:34]=[C:33]([O:35][C:9]2[C:8]([F:11])=[CH:7][C:4]([C:5]#[N:6])=[CH:3][C:2]=2[Cl:1])[CH:32]=[CH:31][C:30]=1[N+:36]([O-:38])=[O:37]

참가 물질

6

반응물 4

HCID 7583Diphenyl EtherHCID 5462222PotassiumHCID 12922678Methyl 5-hydroxy-2-nitrobenzoateHCID 136434703-Chloro-4,5-difluorobenzonitrile

생성물 1

HCID 23035893Methyl-5-(2-chloro-4-cyano-6-fluoro-phenoxy)-2-nitro-benzoate

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

The product 3-chloro-4,5-difluorobenzonitrile, prepared for example as set forth in Example 3, above, is a useful intermediate for the preparation of various end products especially for the preparation of diphenyl ether herbicides. Thus, for example, this compound may be further reacted with the potassium salt of methyl-5-hydroxy-2-nitrobenzoate in a solvent, such as N-methyl-2-pyrrolidone at a temperature of about 120° to 180° Celsius to form methyl-5-(2-chloro-4-cyano-6-fluoro-phenoxy)-2-nitro-benzoate. The ester may be hydrolyzed in a conventional manner to the corresponding carboxylic acid.

후처리

  1. customfor the preparation of various end products

출처 및 근거

ORD 기록
ord-9654b819cb6344e78c270f6b659d72c2
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04590315

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