참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | Salicylic acid, 4-nitro-, methyl ester | HCID 139539 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | Methyl 2-[(methanesulfonyl)oxy]-4-nitrobenzoate | HCID 23320160 | — |
반응 단계
Methyl 2-hydroxy-4-nitrobenzoate (19.7 g) was dissolved in 100 ml of chloroform and triethylamine (15 ml). The solution was kept at a temperature below 15° C., and methanesulfonylchloride (8.6 ml) was added dropwise. The solution was maintained at 50° C. for 1 hr, whereupon it was poured onto ice-hydrochloric acid and extracted with a total of 600 ml chloroform. The solution was dried with magnesium sulfate, treated with active carbon and evaporated. The product was recrystallized from methanol. Yield: 20 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04591584 |
|---|
| 출처 데이터셋 | uspto-grants-1986_05 |
|---|
| ORD ID | ord-e999d4d5001244278c3eb477e6871205 |
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| 출처 메모 | uspto-grants-1986_05 |
|---|
