反应详情

温度

50 °C

Methyl 2-hydroxy-4-nitrobenzoate (19.7 g) was dissolved in 100 ml of chloroform and triethylamine (15 ml). The solution was kept at a temperature below 15° C., and methanesulfonylchloride (8.6 ml) was added dropwise. The solution was maintained at 50° C. for 1 hr, whereupon it was poured onto ice-hydrochloric acid and extracted with a total of 600 ml chloroform. The solution was dried with magnesium sulfate, treated with active carbon and evaporated. The product was recrystallized from methanol. Yield: 20 g.

1. additionwas added dropwise
2. additionwas poured onto ice-hydrochloric acid
3. extractionextracted with a total of 600 ml chloroform
4. dry with materialThe solution was dried with magnesium sulfate
5. additiontreated with active carbon
6. customevaporated
7. customThe product was recrystallized from methanol