Trimethyl phosphite → Phosphinecarboxylic acid, dimethoxy-, cyclohexyl ester, oxide

반응식

C[O:2][P:3]([O:6][CH3:7])[O:4][CH3:5].[CH:8]1([O:14][C:15](Cl)=[O:16])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>>[CH:8]1([O:14][C:15]([P:3](=[O:2])([O:6][CH3:7])[O:4][CH3:5])=[O:16])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

참가 물질

반응물 2

HCID 8472Trimethyl phosphite

HCID 83262Carbonochloridic acid, cyclohexyl ester

생성물 1

HCID 512109Phosphinecarboxylic acid, dimethoxy-, cyclohexyl ester, oxide

실험 절차

From 24.8 g (0.20 mole) of trimethylphosphite and 32.1 g (0.20 mole) of cyclohexylchloroformate, (Y. Iwakura and A. Nabeya, J. Org. Chem. 25 (1960) 1118; M. E. Fourneau et al. Chem. Abstr. 16 (1922) 240; J. H. Saunders et al. J. Am. Chem. Soc. 73 (1951) 3797). (100° C., 2 hours). Yield 30 g (54%). Bp1.4-1.8 148°-151° C. nD21 1.4543.

후처리

custom(100° C., 2 hours)
customBp1.4-1.8 148°-151° C.

출처 및 근거

ORD 기록: ord-3ad9619f081b468097b01c8370df9cbf
출처 데이터셋: uspto-grants-1986_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04591583

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