Dichloromethane → 4-{3-[3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoic Acid Hydrazide

HRID 28222노트

반응식

HRID 28222 반응식
[OH:1][C:2]1([CH2:8][CH2:9][N:10]2[C:14](=[O:15])[CH2:13][S:12][CH:11]2[CH2:16][CH2:17][CH2:18][C:19]2[CH:28]=[CH:27][C:22]([C:23](OC)=[O:24])=[CH:21][CH:20]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.O.[NH2:30][NH2:31].ClCCl>CO>[OH:1][C:2]1([CH2:8][CH2:9][N:10]2[C:14](=[O:15])[CH2:13][S:12][CH:11]2[CH2:16][CH2:17][CH2:18][C:19]2[CH:28]=[CH:27][C:22]([C:23]([NH:30][NH2:31])=[O:24])=[CH:21][CH:20]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 24654Hydrazine hydrate (1:1)HCID 13174084Methyl 4-{3-[3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoate

생성물 1

HCID 867372444-{3-[3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoic Acid Hydrazide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of methyl 4-{3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoate (4.1 g., 0.01 mole) and hydrazine hydrate (2.5 g., 0.05 mole) in methanol (25 ml.) is stored at 25° C. for 48 hours. The solvent is then removed by distillation at reduced pressure. The residue is treated with water and enough 2 N hydrochloric acid to give a neutral mixture. The title compound is isolated by extraction into dichloromethane and subsequent drying and evaporation of the extract.

후처리

  1. customThe solvent is then removed by distillation at reduced pressure
  2. additionThe residue is treated with water and enough 2 N hydrochloric acid
  3. customto give a neutral mixture

출처 및 근거

ORD 기록
ord-cc169145f6f0448d8fe67ce6fc03b3a7
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225609

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