Diflunisal → 2,4-Difluoro-1,1'-biphenyl

HRID 28242

반응식

HRID 28242 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:17]=[C:13](C(O)=O)[C:12](O)=[CH:11][CH:10]=1.FC1C=C(F)C=CC=1N>C1C=CC=CC=1>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:17]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 3059DiflunisalHCID 97092,4-Difluoroaniline

생성물 1

HCID 1699742,4-Difluoro-1,1'-biphenyl

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

5-(2,4-difluorophenyl)salicylic acid, an anti-inflammatory, anti-pyretic, analgesic agent is prepared by: (1) diazotizing 2,4-difluoroaniline in the presence of benzene to yield 2,4-difluorobiphenyl; (2) Friedel-Crafts acylation to produce 2',4'-difluoro-4-alkanoylbiphenyl; (3) oxidation of the alkanoyl group to produce 2',4'-difluoro-4-alkanoyloxybiphenyl; (4) hydrolysis of the alkanoyl group to produce 4-(2,4-difluorophenyl)phenol; and (5) Kolbe-Schmitt carboxylation to produce the final product.

출처 및 근거

ORD 기록
ord-7705dc1856f64654a33eddcb916b1931
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225730

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