tert-Butyl piperazine-1-carboxylate → HCID 68248250, 화합물
반응식
CC(C)(C)OC(=O)N1CCNCC1.COC(=O)c1ccc(I)cc1O>COCCOC.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>COC(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1O참가 물질
7
반응 조건
- 온도
- 90 °C
실험 절차
tert-butyl piperazine-1-carboxylate (0.670 g, 3.60 mmol) and methyl 2-hydroxy-4-iodobenzoate (1 g, 3.60 mmol), BINAP (0.224 g, 0.36 mmol), cesium carbonate (2.461 g, 7.55 mmol) were put inDME (18 mL), tris(dibenzylideneacetone)dipalladium(0) (0.165 g, 0.18 mmol) was added last. Reaction wsa purged by nitrogen, and heated at90 °C overnight. No desired product was found.
출처 및 근거
- ORD 기록
- ord-50654e3db36e4cb59399fcb1f475b246
- 출처 데이터셋
- 750 AstraZeneca ELN dataset
- 원본 링크
- 출처 보기
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