Dimethylamine → Dimethylacetoacetamide

HRID 2851

반응식

HRID 2851 반응식
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[CH3:11][NH:12][CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH3:13])[C:4](=[O:5])[CH2:3][C:2](=[O:6])[CH3:1]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 87118046Diketene acetone

생성물 1

HCID 16278Dimethylacetoacetamide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)

출처 및 근거

ORD 기록
ord-eb592b1203c74e969732293b7513ee02
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731322

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