Sodium Hydroxide → HCID 178418387, 화합물

HRID 2852

반응식

HRID 2852 반응식
[CH3:1][N:2]([CH3:9])[C:3](=[O:8])[CH2:4][C:5](=[O:7])[CH3:6].[OH-].[Na+].[Cl-].[C:13]1([N+:19]#[N:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>O>[CH3:1][N:2]([CH3:9])[C:3](=[O:8])[C:4](=[N:20][NH:19][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:5](=[O:7])[CH3:6]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 16278DimethylacetoacetamideHCID 60992Benzenediazonium chloride

생성물 1

HCID 178418387HCID 178418387, 화합물수율 42.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4.5 g (0.035 mol) of N,N-dimethyl-3-oxobutyramide, a solution of 4.9 g (0.122 mol) of NaOH in 45 ml of water and 0.037 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 0%→100%) obtaining 3.5 g of the title compound which was used as such in the subsequent step. M.p.=131°-133° C.

후처리

  1. customas described in preparation 8
  2. customThe crude reaction mixture
  3. customwas purified by chromatography on silica gel (hexane/Et2O 0%→100%)

출처 및 근거

ORD 기록
ord-b070703fd73b4d8680fe6f71c91c67d7
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731322

연결된 노트

불러오는 중…