Sodium Hydroxide → HCID 178418482, 화합물

HRID 2853

반응식

HRID 2853 반응식
[O:1]=[C:2]([CH3:7])[CH2:3][C:4]([NH2:6])=[O:5].[OH-].[Na+].[Cl-].[C:11]1([N+:17]#[N:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[C:11]1([NH:17][N:18]=[C:3]([C:2](=[O:1])[CH3:7])[C:4]([NH2:6])=[O:5])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 60992Benzenediazonium chlorideHCID 80077Acetoacetamide

생성물 1

HCID 178418482HCID 178418482, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

5.0 g (0.049 mol) of 3-oxobutyramide, a solution of 6.9 g (0.171 mol) of NaOH in 75 ml of water and 0.051 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel(EtOAc) obtaining 3 g of the title compound which was used as such in the subsequent step. M.p.=146°-147° C.

후처리

  1. customas described in preparation 8
  2. customThe crude reaction mixture
  3. customwas purified by chromatography on silica gel(EtOAc) obtaining 3 g of the title compound which

출처 및 근거

ORD 기록
ord-fa496a7ce126439c8a04c703ffcedc08
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731322

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