2,2,2-Trifluoroethyl trifluoromethanesulfonate → 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene

HRID 28609

반응식

HRID 28609 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.BrC1C=C(Cl)C=CC=1O[CH2:18][C:19]([F:22])([F:21])[F:20].FC(F)(F)COS(C(F)(F)F)(=O)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:18][C:19]([F:22])([F:21])[F:20])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 865946032-Bromo-4-chloro-1-(2,2,2-trifluoro-ethoxy)-benzene 4-bromo-phenol

생성물 1

HCID 229138831-Bromo-4-(2,2,2-trifluoroethoxy)benzene수율 40%

실험 절차

Following the method described in Example 89 for the synthesis of 2-bromo-4-chloro-1-(2,2,2-trifluoro-ethoxy)-benzene 4-bromo-phenol and trifluoro-methanesulfonic acid 2,2,2-trifluoro-ethyl ester gave 1-bromo-4-(2,2,2-trifluoro-ethoxy)-benzene (40% yield). 1H NMR (acetone-d6) δ 4.68 (q, 2H, J=8.5 Hz, CH2), 7.04 (d, 2H, J=9.1 Hz, Ar), 7.49 (d, 2H, J=9.1 Hz, Ar).

출처 및 근거

ORD 기록
ord-c912224cf53a4801a4416a5bc234448f
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

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