4-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine → 4-(5-Bromo-2-butoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

HRID 28640

반응식

HRID 28640 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][CH2:18][CH3:19])=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH2:15])[N:9]=2)[CH:7]=1.N[C:21]1N=C(C2C=C(Br)C=CC=2O)C=C(Cl)N=1>C(O)CCC>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][CH2:18][CH2:19][CH3:21])=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH2:15])[N:9]=2)[CH:7]=1

참가 물질

4

반응물 2

HCID 860043744-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamineHCID 1360800122-(2-Amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

생성물 1

HCID 860043844-(5-Bromo-2-butoxy-phenyl)-6-chloro-pyrimidin-2-ylamine수율 51%

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and butan-1-ol provided 4-(5-bromo-2-butoxy-phenyl)-6-chloro-pyrimidin-2-ylamine (51% yield).

출처 및 근거

ORD 기록
ord-1d14790471564a5b97e0d580c9fee8c2
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

연결된 노트

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