Hydrochloric Acid → 4-Anilino-3-nitrobenzoic acid

HRID 28663

반응식

HRID 28663 반응식
F[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.Cl>C(O)C.O>[NH:14]([C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 679874-Fluoro-3-nitrobenzoic acid

생성물 1

HCID 38243664-Anilino-3-nitrobenzoic acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

4-Fluoro-3-nitrobenzoic acid (21.6 mmol) and an aniline (43.2 mmol) in 15 mL of ethanol were stirred at reflux under argon for 5 h resulting in the formation of an orange precipitate. After 12 h the heterogeneous reaction mixture was poured into 50 mL of 1N HCl(aq) and diluted with 100 mL of water. The solution was stirred for 20 min then the precipitate filtered to yield the 4-anilino-3-nitrobenzoic Acid: e.g. 4-{[3-(benzyloxy)phenyl]amino}-3-nitrobenzoic acid.

후처리

  1. temperatureat reflux under argon for 5 h
  2. customresulting in the formation of an orange precipitate
  3. filtrationthe precipitate filtered

출처 및 근거

ORD 기록
ord-8ab56e89eb204695b2ea7c0c30ec3f5d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419995B2

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