Guanidine → N-diaminomethylene-3-methylsulfonyl-4-(1-cyclopenten-3-yl)benzamide

반응식

[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[CH:14]1[CH2:18][CH2:17][CH:16]=[CH:15]1)[C:8](Cl)=[O:9])(=[O:4])=[O:3].[NH2:19][C:20]([NH2:22])=[NH:21]>>[NH2:21][C:20]([NH2:22])=[N:19][C:8](=[O:9])[C:7]1[CH:11]=[CH:12][C:13]([CH:14]2[CH2:18][CH2:17][CH:16]=[CH:15]2)=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH:6]=1

참가 물질

반응물 2

HCID 3520Guanidine

HCID 196882683-Methylsulfonyl-4-(1-cyclopenten-3-yl)-benzoyl chloride

생성물 1

HCID 19688175N-diaminomethylene-3-methylsulfonyl-4-(1-cyclopenten-3-yl)benzamide

실험 절차

Analogously to Example 1, by reaction of 2.2 g of 3-methylsulfonyl-4-(1-cyclopenten-3-yl)-benzoyl chloride with guanidine, customary working up gives N-diaminomethylene-3-methylsulfonyl-4-(1-cyclopenten-3-yl)benzamide, which can be recrystallized from acetonitrile/diethylether, m.p. 188°-190°.

출처 및 근거

ORD 기록: ord-90f641ecf797467592f5799ba146037c
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05731351

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