Methyl iodide → 5-Chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

HRID 29384노트

반응식

HRID 29384 반응식
[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([OH:17])[C:9]=2[C:10]=1[CH3:11])=[O:5])[CH3:2].IC.[C:20]([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([O:17][CH3:20])[C:9]=2[C:10]=1[CH3:11])=[O:5])[CH3:2]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 687146975-Chloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

생성물 1

HCID 687120345-Chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester수율 94%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 5-chloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (120 mg, 0.47 mmol) was added 0.3 mL (4.7 mmol) of iodomethane, 130 mg (2 eq) of K2CO3 and 4 mL of DMF. The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined organic solution was washed with brine and water. Removal of the solvent in vacuo gavel 19 mg (94% yield) of 5-chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester as a white solid.

후처리

  1. washThe mixture was washed with brine
  2. extractionextracted with ethyl acetate
  3. washThe combined organic solution was washed with brine and water

출처 및 근거

ORD 기록
ord-ca8c8c18006a4cc6a15b6364c4e26db5
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07420001B2

반응 노트

불러오는 중…