Methyl iodide → 4-Methoxy-3,5-dimethyl-benzofuran-2-carboxylic acid tert-butyl ester

HRID 29424노트

반응식

HRID 29424 반응식
[C:1]([O:5][C:6]([C:8]1[O:9][C:10]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([OH:19])[C:11]=2[C:12]=1[CH3:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].IC.[C:22]([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[C:1]([O:5][C:6]([C:8]1[O:9][C:10]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([O:19][CH3:22])[C:11]=2[C:12]=1[CH3:13])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 68707780HCID 68707780, 화합물

생성물 1

HCID 687166394-Methoxy-3,5-dimethyl-benzofuran-2-carboxylic acid tert-butyl ester수율 97.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 80 mg of 4-hydroxy-3,5-dimethyl-benzofuran-2-carboxylic acid tert-butyl ester was added 1 mL of iodomethane, 80 mg of K2CO3 and 1 mL of DMF. The mixture was stirred at room temperature overnight. The reaction mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate solution was washed with brine. Removal of the solvent gave 82 mg of 4-methoxy-3,5-dimethyl-benzofuran-2-carboxylic acid tert-butyl ester as a pale yellow solid.

후처리

  1. washThe reaction mixture was washed with brine
  2. extractionextracted with ethyl acetate
  3. washThe combined ethyl acetate solution was washed with brine
  4. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-03cc3561d1534fcab575109e3b194a44
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07420001B2

반응 노트

불러오는 중…