Sodium Hydroxide → Sodium 5-chloro-1,3-benzothiazole-2-carboxylate

HRID 29445노트

반응식

HRID 29445 반응식
C([O:3][C:4]([C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:9]=2[N:10]=1)=[O:5])C.[OH-].[Na+:17]>C1COCC1>[Na+:17].[Cl:15][C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([C:4]([O-:5])=[O:3])=[N:10][C:9]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 63357893Ethyl 5-chloro-1,3-benzothiazole-2-carboxylate

생성물 1

HCID 68717138Sodium 5-chloro-1,3-benzothiazole-2-carboxylate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 5-chloro-benzothiazole-2-carboxylic acid ethyl ester (200 mg, 0.83 mmol) was added 3 mL of THF, and 0.83 mL (2 eq) of NaOH solution (2N in MeOH). The reaction mixture was stirred at room temperature overnight. The suspension was filtered and the solid was dried under vacuum to give 170 mg of 5-chloro-benzothiazole-2-carboxylic acid sodium salt as an off-white solid.

후처리

  1. filtrationThe suspension was filtered
  2. customthe solid was dried under vacuum

출처 및 근거

ORD 기록
ord-fc3d1e80ce71433185d60e5556f9662d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07420001B2

반응 노트

불러오는 중…