2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → 2-[2-Methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran

참여 물질

역할	이름	HCID	투입량
반응물	2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol	HCID 2734650	—
반응물	2-(Bromomethyl)-1-benzofuran	HCID 12326316	—
생성물	2-[2-Methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran	HCID 68713822	29%

반응 단계

Alkylation of 2-bromomethyl-benzofuran with 2-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol was carried out according to Example 136, Step 3, to give 2-[2-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran in 29% yield. 1H NMR (400 MHz, CDCl3) δ ppm 1.3 (s, 12 H) 3.9 (s, 3 H) 5.3 (s, 2 H) 6.8 (d, J=0.8 Hz, 1 H) 7.0 (d, J=8.1 Hz, 1 H) 7.2 (m, 1 H) 7.3 (m, 2 H) 7.4 (dd, J=8.0, 1.4 Hz, 1 H) 7.5 (dd, J=8.1, 0.8 Hz, 1 H) 7.5 (dd, J=8.0, 1.1 Hz, 1 H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07420001B2
출처 데이터셋	uspto-grants-2008_09
ORD ID	ord-a4ace0e66ecc4feb8f46b4b616f93627
출처 메모	uspto-grants-2008_09