Sodium Acetate → 5-[(3,5-Di-2-propenyl-4-hydroxyphenyl)-methylene]-2-thioxo-4-thiazolidinone

HRID 2949

반응식

HRID 2949 반응식
[CH2:1]([C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([CH2:13][CH:14]=[CH2:15])[C:11]=1[OH:12])[CH:7]=O)[CH:2]=[CH2:3].[S:16]1[CH2:22][C:20](=[O:21])[NH:19][C:17]1=[S:18].C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH2:1]([C:4]1[CH:5]=[C:6]([CH:7]=[C:22]2[S:16][C:17](=[S:18])[NH:19][C:20]2=[O:21])[CH:9]=[C:10]([CH2:13][CH:14]=[CH2:15])[C:11]=1[OH:12])[CH:2]=[CH2:3]

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 120477783,5-Di-(2-propenyl)-4-hydroxybenzaldehyde

생성물 1

HCID 540052885-[(3,5-Di-2-propenyl-4-hydroxyphenyl)-methylene]-2-thioxo-4-thiazolidinone수율 94.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3,5-di-(2-propenyl)-4-hydroxybenzaldehyde (50.5 g), 36.6 g of rhodanine and 164 g of sodium acetate were heated together at reflux temperature in 1.25 liter of acetic acid for 14.5 hours. The resultant solution was cooled, poured into 2 liter of ice water to yield, upon separation, about 75 g of 5-[(3,5-di-2-propenyl-4-hydroxyphenyl)-methylene]-2-thioxo-4-thiazolidinone, m.p. 157°-160° C.

출처 및 근거

ORD 기록
ord-0c27d491eec04e228dfd3d1e3bf80bcf
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731336

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