Tetrahydrofuran → 4-Biphenylsulfonic acid, 4'-amino-

HRID 29494

반응식

HRID 29494 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([OH:19])(=[O:18])=[O:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O.[Sn](Cl)Cl.C1COCC1>O>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([OH:19])(=[O:17])=[O:18])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 24479Stannous ChlorideHCID 534258824'-Nitro-4-biphenylsulfonic acid

생성물 1

HCID 957994-Biphenylsulfonic acid, 4'-amino-수율 73.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4′-Nitro-biphenyl-4-sulfonic acid (1.12 g, 4 mmol) was mixed with tin (II) chloride (5.2 g, 32 mmol) and 40 ml of THF. The mixture was refluxed overnight. The reaction mixture was poured into 80 ml of water and stirred at room temperature for 8 h. The mixture was filtered and the solid was dried under vacuum to provide 0.73 g (73%) of 4′-amino-biphenyl-4-sulfonic acid, obtained as an off-white solid.

후처리

  1. temperatureThe mixture was refluxed overnight
  2. filtrationThe mixture was filtered
  3. customthe solid was dried under vacuum

출처 및 근거

ORD 기록
ord-a520dcafb84945c88476d716e5caae5b
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07420001B2

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