Chlorosulfonic acid → 2-Oxazol-5-YL-benzenesulfonyl chloride

HRID 29522노트

반응식

HRID 29522 반응식
[C:1]1([C:7]2[O:11][CH:10]=[N:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:12][S:13](O)(=[O:15])=[O:14]>C(Cl)(Cl)Cl>[O:11]1[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][C:6]=2[S:13]([Cl:12])(=[O:15])=[O:14])=[CH:8][N:9]=[CH:10]1

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 5893115-Phenyl oxazole

생성물 1

HCID 552794732-Oxazol-5-YL-benzenesulfonyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
70 °C

실험 절차

5-Phenyloxazole (2.0 g, mmol) in chloroform (50 ml) was cooled to 0° C. using an ice bath. Chlorosulfonic acid 4.8 g (2.7 ml, 3 eq) of was added slowly with stirring. The reaction mixture was heated to 70° C. for 16 h. The reaction mixture was then cooled to RT, quenched with ice and extracted with chloroform. The organic layer was washed with cold water, brine and concentrated. The brown solid obtained was purified by column chromatography using 5% ethyl acetate in pet ether as eluent, to yield a yellow solid.

후처리

  1. temperatureThe reaction mixture was then cooled to RT
  2. customquenched with ice
  3. extractionextracted with chloroform
  4. washThe organic layer was washed with cold water, brine
  5. concentrationconcentrated
  6. customThe brown solid obtained
  7. customwas purified by column chromatography
  8. customto yield a yellow solid

출처 및 근거

ORD 기록
ord-77ee1a4a12604140807a12e2e1e125b3
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07420055B2

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