Benzyl Bromide → 2-Benzylcaprolactone

HRID 2969

반응식

HRID 2969 반응식
[C:1]1(=[O:8])[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Li+].CC([N-]C(C)C)C.[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1COCC1.CN1C(=O)N(C)CCC1>[CH2:17]([CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:1]1=[O:8])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

6

반응물 3

HCID 7498Benzyl BromideHCID 10401epsilon-CAPROLACTONEHCID 2724682Lithium diisopropylamide

생성물 1

HCID 151887982-Benzylcaprolactone

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-용매

실험 절차

A solution of 1 mmol of caprolactone in 0.5 mL THF was added to a solution of LDA in 0.5 mL THF at -78° C. and this stirred for 2 h. Then a solution of 1.1 mmol of a benzylbromide in 0.14 mL DMPU was added to the above mixture and after stirring for 1 h at -15° C., the 2-benzylcaprolactone was isolated by extraction and chromatography.

후처리

  1. stirringafter stirring for 1 h at -15° C.

출처 및 근거

ORD 기록
ord-1c2ee4b9716b4027b28c9669b15472c1
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731432

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