Dimethylformamide → HCID 178418432, 화합물

반응식

Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].C([N:11]([CH2:14]C)CC)C.C1([N:22]=[C:23]=[N:24][CH:25]2[CH2:30][CH2:29][CH2:28]CC2)CCCCC1.O[N:32]1[C:36](=O)[CH2:35][CH2:34][C:33]1=[O:38].CN(C=[O:43])C>>[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH:7][C:33](=[O:38])[CH2:34][CH2:35][CH2:36][N:32]1[C:25]2[N:24]=[CH:23][NH:22][CH2:28][CH:29]([OH:43])[C:30]=2[N:11]=[CH:14]1)[CH3:3]

참가 물질

반응물 5

HCID 6228Dimethylformamide

HCID 8471Triethylamine

HCID 10868Dicyclohexylcarbodiimide

HCID 80170N-Hydroxysuccinimide

HCID 2723640Glycine ethyl ester, hydrochloride

생성물 1

HCID 178418432HCID 178418432, 화합물

실험 절차

A mixture of 1 mmol of 3-(3'-carbobenzyloxypropyl)coformycin aglycone and10 mg of 10% Pd/C in 4 mL of methanol was subjected to hydrogenation. After filtration and removal of the solvent, 3-(3'-carboxypropyl)coformycin aglycone was obtained. This product, 2 mmol glycine ethyl ester hydrochloride, 2 mmol triethylamine, 2 mmol dicyclohexylcarbodiimide and 2 mmol N-hydroxysuccinimide in 10 mL DMF were stirred 16 h and filtered. Chromatography provided N-(4-(3,6,7,8-tetrahydro-imidazo[4,5-d]-[1,3]diazepin-8-ol-3-yl)butyryl)glycine ethyl ester.