Water → methyl 3-[N'-benzyloxycarbonyl-hydrazinocarbonyl)-benzoate

HRID 29803

반응식

HRID 29803 반응식
Cl[C:2]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])=[O:3].[NH:14]([C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])[NH2:15].O>C(OCC)C.ClCCl.N1C=CC=CC=1>[CH2:19]([O:18][C:16]([NH:14][NH:15][C:2]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])=[O:3])=[O:17])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

7

반응물 3

HCID 962WaterHCID 79242Benzyl carbazateHCID 15563901Methyl 3-(chlorocarbonyl)benzoate

생성물 1

HCID 12571328methyl 3-[N'-benzyloxycarbonyl-hydrazinocarbonyl)-benzoate

시약·촉매·용매 3

HCID 1049Pyridine용매HCID 3283Diethyl Ether용매2회HCID 6344Dichloromethane용매

실험 절차

10.80 g (54.4 mmol) methyl 3-chlorocarbonyl-benzoate in 100 mL diethyl ether are added dropwise to a solution of 9.04 g (54.4 mmol) benzyl hydrazine carboxylate in 100 mL diethyl ether, 100 mL dichloromethane and 4.83 mL pyridine while cooling with an ice bath. The reaction mixture is stirred overnight at ambient temperature and then combined with water. The precipitated solid is filtered off and washed with diethyl ether. White solid.

후처리

  1. temperaturewhile cooling with an ice bath
  2. filtrationThe precipitated solid is filtered off
  3. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-a1590d231f5e491abba1d3b8bec6d5a0
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423036B2

연결된 노트

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