Acetic Anhydride → N-(3-Bromo-4-methylphenyl)acetamide

HRID 29819

반응식

HRID 29819 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[CH3:9])[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[C:10]([NH:5][C:4]1[CH:6]=[CH:7][C:8]([CH3:9])=[C:2]([Br:1])[CH:3]=1)(=[O:12])[CH3:11]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 82187Benzenamine, 3-bromo-4-methyl-

생성물 1

HCID 11708413N-(3-Bromo-4-methylphenyl)acetamide수율 99.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-bromo-4-methylaniline (1.27 g, 6.82 mmol) in DCM (20 mL) at (0° C. is added acetic anhydride (0.676 mL, 7.16 mmol) dropwise. After 30 minutes, the mixture is partitioned between DCM and saturated sodium carbonate solution. The layer is separated and the aqueous layer is extracted with DCM. The combined organic extracts are washed with brine, dried over Na2SO4, filtered and concentrated to afford the title compound (1.55 g, 99%). The residue is used in the next step without further purification.

후처리

  1. customthe mixture is partitioned between DCM and saturated sodium carbonate solution
  2. customThe layer is separated
  3. extractionthe aqueous layer is extracted with DCM
  4. washThe combined organic extracts are washed with brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b205cd67cc5f4963b841b1479888a34a
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423038B2

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