Potassium Carbonate → n-[8-(Naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide

HRID 29927

반응식

HRID 29927 반응식
[CH:1]12[NH:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][CH:3]([NH:9][C:10](=[O:12])[CH3:11])[CH2:2]2.C(N1CCC(NC2[C:36]3[C:31](=[C:32](OC)[CH:33]=[C:34](OC)[CH:35]=3)[C:30]([C:41]3[CH:46]=[CH:45]C(OC)=C[CH:42]=3)=NN=2)CC1)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+].BrCC1C=CC2C(=CC=CC=2)C=1.[OH-].[Na+]>CC(C)=O>[CH:30]1[C:31]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:45]=[CH:46][C:41]=1[CH2:42][N:8]1[CH:5]2[CH2:6][CH2:7][CH:1]1[CH2:2][CH:3]([NH:9][C:10](=[O:12])[CH3:11])[CH2:4]2

참가 물질

7

반응물 5

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 703202-BromomethylnaphthaleneHCID 652782N-(8-Aza-bicyclo[3.2.1]oct-3-yl)-acetamideHCID 69213501N-(1-benzylpiperidin-4-yl)-5,7-dimethoxy-4-(4-methoxyphenyl)phthalazin-1-amine

생성물 1

HCID 69214902n-[8-(Naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide수율 84%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

1.6 g (9.5 mmol) of N-[8-azabicyclo[3.2.1]oct-3-yl]acetamide prepared according to Dostert et al. (European Journal of Medicinal Chemistry 1984, 19 (2), 105-110) are dissolved in 45 mL of acetone, and 5.2 g of potassium carbonate and 2.5 g (11.4 mmol) of 2-(bromomethyl)naphthalene are added. The mixture is refluxed with stirring for 18 hours. After cooling, the acetone is partially evaporated off. Water is added to the residue, and the mixture is extracted with dichloromethane. The organic phase is extracted with 1N hydrochloric acid. The acidic aqueous phase obtained is basified with 1N sodium hydroxide and then extracted with dichloromethane. The extract is washed with water and with brine, dried over anhydrous sodium sulfate and then evaporated under reduced pressure. The residue obtained is filtered on silica gel (solvent: 95/5 (v/v) dichloromethane/methanol). 2.2 g of a pasty oil are obtained (84% yield).

후처리

  1. temperatureThe mixture is refluxed
  2. temperatureAfter cooling
  3. customthe acetone is partially evaporated off
  4. additionWater is added to the residue
  5. extractionthe mixture is extracted with dichloromethane
  6. extractionThe organic phase is extracted with 1N hydrochloric acid
  7. customThe acidic aqueous phase obtained
  8. extractionextracted with dichloromethane
  9. washThe extract is washed with water and with brine
  10. dry with materialdried over anhydrous sodium sulfate
  11. customevaporated under reduced pressure
  12. customThe residue obtained
  13. filtrationis filtered on silica gel (solvent: 95/5 (v/v) dichloromethane/methanol)

출처 및 근거

ORD 기록
ord-1f91637baf4f4351af4521a0e5eabbb3
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423030B2

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