Hydrochloric Acid → 5-Methoxy-2-(3-methylbut-2-enyloxy)benzaldehyde

HRID 30093

반응식

HRID 30093 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH:4]=[O:5].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][CH:20]=[C:21]([CH3:23])[CH3:22].Cl>CN(C)C=O.C(OCC)(=O)C>[CH3:11][O:10][C:7]1[CH:8]=[CH:9][C:2]([O:1][CH2:19][CH:20]=[C:21]([CH3:23])[CH3:22])=[C:3]([CH:6]=1)[CH:4]=[O:5]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 700922-Butene, 1-bromo-3-methyl-HCID 956952-Hydroxy-5-methoxybenzaldehyde

생성물 1

HCID 105849975-Methoxy-2-(3-methylbut-2-enyloxy)benzaldehyde

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-hydroxy-5-methoxybenzaldehyde (7.6 g, 50 mmol) in dry N,N-dimethylformamide (100 mL) was added potassium carbonate (10.4 g), followed by 1-bromo-3-methylbut-2-ene (10.0 g, 67 mmol). The mixture was stirred at room temperature for 48 hours and ethyl acetate added. Sufficient 1M hydrochloric acid was cautiously added to neutralize the base, and the organic layer was washed with water three times, followed by brine, and dried over magnesium sulfate. The mixture was filtered, and solvent removed from the filtrate under reduced pressure, to provide 5-methoxy-2-(3 -methylbut-2-enyloxy)benzaldehyde.

후처리

  1. washthe organic layer was washed with water three times
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe mixture was filtered
  4. customsolvent removed from the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-06f988e364c540fbacba7f1878f5c21d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423045B2

연결된 노트

불러오는 중…