4-Bromothiophene-2-carbaldehyde → 3-(4-Bromo-thiophen-2-yl)-acrylic acid methyl ester

HRID 30291

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=O)[S:5][CH:6]=1.[CH3:9][O:10][C:11](=[O:27])[CH2:12]P(OCC(F)(F)F)(OCC(F)(F)F)=O>>[CH3:9][O:10][C:11](=[O:27])[CH:12]=[CH:7][C:4]1[S:5][CH:6]=[C:2]([Br:1])[CH:3]=1

참가 물질

반응물 2

HCID 877924-Bromothiophene-2-carbaldehyde

HCID 184894Nsc 634137

생성물 1

HCID 541625193-(4-Bromo-thiophen-2-yl)-acrylic acid methyl ester수율 78%

실험 절차

4-Bromo-thiophene-2-carbaldehyde (44 g, 0.23 mol) and [Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic methyl ester (80.6 g, 0.253 mol) were treated by the method outlined in Example 34, step a) to afford the subtitle compound that was purified by column chromatography (SiO2) using a 0-60% ethylacetate-hexane gradient (46.22 g, yield: 78%). MS calculated for C8H7BrO2S+H: 247, observed: 247 249.

출처 및 근거

ORD 기록: ord-f2db750a4b23425ba000baac5c129435
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07423056B2

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