2-Thiophenecarboxaldehyde → Methyl 3-(thiophen-2-yl)acrylate

반응식

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.[CH3:8][O:9][C:10](=[O:26])[CH2:11]P(OCC(F)(F)F)(OCC(F)(F)F)=O>>[CH3:8][O:9][C:10](=[O:26])[CH:11]=[CH:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 73642-Thiophenecarboxaldehyde

HCID 184894Nsc 634137

생성물 1

HCID 2778970Methyl 3-(thiophen-2-yl)acrylate수율 75%

실험 절차

Thiophene-2-carbaldehyde (4.00 g, 35.7 mmol) and [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid methyl ester (12.5 g, 39.3 mmol) were treated by the method outlined in Example 34, step a to afford the subtitle compound (4.5 g, yield: 75%). MS calculated for C8H8O2S+H: 169, observed: 169.

출처 및 근거

ORD 기록: ord-af0c01bc0e364401b9be3bda4a583535
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07423056B2

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