반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8]Cl)=[N:6][CH:7]=1.[C:10]1([CH2:16][C:17](=O)[CH3:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.ClC1C=CC(CBr)=CC=1.[N:29]1C=CC=C(CC(=O)C)C=1>>[ClH:1].[NH2:29][CH:17]([CH:16]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)[CH3:18]참가 물질
5
실험 절차
5-Chloro-2-choromethylpyridine (Weidmann, K. et al. J. Med. Chem. 1992, 35, 438) and phenylacetone were used in place of 4-chlorobenzyl bromide and 3-pyridylacetone in Step A of Reference Example 4. LC-MS: m/e 261 (M+H)+.
출처 및 근거
- ORD 기록
- ord-05e047b6489b44479102905253a5f15f
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07423067B2
연결된 노트
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