Phenylacetone → 2-Amino-4-(5-chloro-2-pyridyl)-3-phenylbutane hydrochloride salt

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8]Cl)=[N:6][CH:7]=1.[C:10]1([CH2:16][C:17](=O)[CH3:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.ClC1C=CC(CBr)=CC=1.[N:29]1C=CC=C(CC(=O)C)C=1>>[ClH:1].[NH2:29][CH:17]([CH:16]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)[CH3:18]

참가 물질

반응물 4

HCID 7678Phenylacetone

HCID 693291-(Bromomethyl)-4-chlorobenzene

HCID 2384143-Acetonylpyridine

HCID 145171515-Chloro-2-(chloromethyl)pyridine

생성물 1

HCID 222705172-Amino-4-(5-chloro-2-pyridyl)-3-phenylbutane hydrochloride salt

실험 절차

5-Chloro-2-choromethylpyridine (Weidmann, K. et al. J. Med. Chem. 1992, 35, 438) and phenylacetone were used in place of 4-chlorobenzyl bromide and 3-pyridylacetone in Step A of Reference Example 4. LC-MS: m/e 261 (M+H)+.

출처 및 근거

ORD 기록: ord-05e047b6489b44479102905253a5f15f
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07423067B2

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