3-(Trifluoromethyl)benzylamine → 6-[[3-(Trifluoromethyl)phenyl]methylamino]pyridine-3-carboxamide
반응식
NC(=O)c1ccc(Cl)nc1.NCc1cccc(C(F)(F)F)c1>CC(=O)O.CC(=O)O.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COCCOC.[Na+].[Pd]>NC(=O)c1ccc(NCc2cccc(C(F)(F)F)c2)nc1참가 물질
7
반응물 2
생성물 1
시약·촉매·용매 4
반응 조건
- 온도
- 120 °C
실험 절차
To a stirred solution of 6-chloronicotinamide (0.053 g, 0.34 mmol), sodium 2-methylpropan-2-olate (0.065 g, 0.68 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (0.020 g, 0.03 mmol) and diacetoxypalladium (7.60 mg, 0.03 mmol) in DME (1 mL) was added (3-(trifluoromethyl)phenyl)methanamine (0.049 mL, 0.34 mmol). The reaction was run in microwave at 120 C for 4h. only traces of product observed. Reaction wasted.
출처 및 근거
- ORD 기록
- ord-058876800e774f05bf1b52bd00238231
- 출처 데이터셋
- 750 AstraZeneca ELN dataset
- 원본 링크
- 출처 보기
반응 노트
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